What happened in Peru? (part 1)

Everyone wants to know “what happened in Peru?”

Or, more accurately, they wanted to know, back in December when I had just returned. Unfortunately, I turned out to be incapable of writing about it at the time. In fact, it’s only recently that I’ve started to feel as if I have any kind of handle on what happened. So, for the next few days I’m going to try and get back to that particular mindset as best I can and put something together in some reasonable fashion. I may digress and discuss other things that might seem unconnected that will hopefully become more clear as this goes on, though it’s entirely possible they won’t. This might end up being terribly long (in return for which I’ll break it into more manageable bits), though again it’s also possible I might get two paragraphs in and find I have nowhere to go. In which case, well, that’s already one paragraph gone right there.

(Some of you might rightly wonder why I’m talking about Peru in the first place. Severe clinical depression, my friends, better explained HERE.)

The short version is that Peru was amazing. Life-changing. But it’s all still up for grabs as to what it’s changing into.

First, the context: When I was younger, I smoked pot infrequently and usually to little effect. I never developed any kind of taste for alcohol. On the rare occasions I drank I did it at parties in order to get drunk, and since I grew up shy and introverted I didn’t go to a lot of parties. I also did LSD four times, the most recent being roughly twenty years ago. That’s pretty much a full accounting of the illicit substances I’ve ingested in my life. Of those, only LSD made any kind of impact on my worldview. It didn’t shatter worlds, but it did make their foundations shaky. I knew after the first time I tried it that I had become a different person, or at least now saw the world in a different way. I still think that everyone should try it at least once, I mean, accept or reject what it shows you, but at least look. But, hey, that’s me, and anyway that isn’t the point of writing this.

No, the point is that I’ve tried illegal drugs, found worth in some, less in others. None of them developed into anything anyone could reasonably call a ‘habit.’

More context: I’ve seen various doctors, psychiatrists and therapists to help deal with the severe depression I’ve battled over the past fifteen years or so. This depression, it seems to me, is largely situational and self-inflicted. It stems from certain behaviors and choices and their accompanying guilt and regret, and was exacerbated by a powerful ability to look the other way and convince myself that the cause and effect were unrelated. The particulars are important personally, but they don’t have anything to do with the point of writing this.

No, the point is I’ve also tried a good number of legal drugs, found worth in some, less in others. Certainly, the amount of Prozac, Wellbutrin, Celexa, Effexor, etc. that has been pumped into my system over the last fifteen years is far in excess of the more illegal psychoactive drugs I experimented with in my early twenties. None of them provided any positive results that anyone could reasonably call ‘permanent.’

So, that’s the landscape that more or less existed last November when I wrote that I was going to Peru to take ayahuasca. At the time I didn’t bother to explain what ayahuasca was because, you know, I assume everyone knows everything I do. “Ayahuasca” is a psychoactive brew made from the ayahuasca vine and chacruna leaves, that’s been used by indigenous Amazonian cultures as a religious sacrament and healing medicine for thousands of years.

“Chacruna leaves contain DMT, a powerful hallucinogen that’s orally inactive. But it’s dissolved in the stomach [by] monoamine oxydase. They mix chacruna leaves with ayahuasca, which contains several substances that inhibit the stomach enzyme. By cooking the two plants together for hours, it produces a drink that contains orally active DMT and the molecule is absorbed through the stomach intact and goes to the brain. How could they have discovered this recipe when we know there are 80,000 species of evolved plants in the Amazon? Any given combination would give only a one in six billion chance of finding it.”
– Jeremy Narby, anthropologist

DMT also happens to be a Schedule I drug, which creates the odd situation in the US where it would be legal to grow ayahuasca and chacruna but illegal to mix and ingest them.

My first serious exposure to the drug was stumbling onto an article in National Geographic, by a writer who suffered from meds-resistant depression, who had read some of the scientific studies involving the use of psychedelics in treating depression (ayahuasca in particular), and decided to travel to Peru to participate in an ayahuasca ceremony. Her experiences (the article was written during a return visit) struck a chord with me and, when eventually my own situation deteriorated to the point where electro-convulsive therapy was being suggested, I decided I had nothing to lose in trying something seemingly crazy.

In the airplane, over Peru

Next time: I leave and arrive.

Wits’ end

I started talking about this on a different blog, a personal one. But it’s a sign of certain aspects of my depression that I can’t ever really seem to pick one idea as correct and stick with it. So now it seems odd to not follow through here in this blog having already discussed depression to some length. So I’m adding this one here, which some of you will have already seen a couple of weeks ago. Sometime after, I’ll update on the trip to Peru and other odds and ends.

The past few (or many, I suppose) months I’ve gotten more and more frustrated. It’s not so much that the depression is so bad, I mean, my dark depression comes and goes, you know, and the drugs do seem to keep me out of it for the most part. But this whole thing of not caring about things or having any kind of motivation… I mean, my small victories are in the days where I actually leave the house for whatever small reason. And it dawned on me (well, not exactly, it’s not like I didn’t already know, more that it just really struck me) that it’s been going on for a decade. I realize that new meds give me that initial surge, but I think it’s more about the depression being lifted and feeling relief, and then shortly thereafter that wears off and I realize I’m still feeling the other stuff. The anhedonia. I’ve been going to therapy again for I guess about 6 months now. Kaiser wants to add a third medicine (Lamictal), which is supposed to be a mood stabilizer, in addition to the Wellbutrin and Zoloft. But that doesn’t even make much sense to me since my moods aren’t really swinging that wildly, it’s just that my level points are still fairly low.

The topic of ECT has finally been brought into serious conversation at this point. I realize it’s not the thing that it’s been portrayed as in popular culture, but even so… I’m not wild about the idea. Some people suffer short term memory loss. And then the step after that is deep brain stimulation, which involves putting a damn chip in my head to act as a sort of brain pacemaker. I mean, if it were 15 years ago when I was all into cyberpunk, I’m sure that would have been cool. But these days, not so much. All this with the knowledge that THEY DON’T EVEN KNOW WHAT CAUSES DEPRESSION OR HOW THE TECHNIQUES THEY USE TO TREAT IT WORK. WHEN they work, which for me hasn’t been the case.

I just don’t know what else to try… for a while, before they added the Zoloft, I was trying this other thing, based on the idea that there were chemical imbalances and there were supplements you could take to help; fish oil, l-carnitine, coQ10, etc. So I took those along with the meds for about 2 months. I never really noticed any difference. The drop I had that led to them switching Effexor for Zoloft happened while I was still taking the supplements. They ran out shortly after and I didn’t bother getting more, and I didn’t have any kind of drop from them being gone.

It’s weird, the depression is sort of disconnected in some ways, but I’m also really aware of it. A couple of nights ago I had a low night, but I announced it was coming beforehand because I could feel it, then I started to cry, while I was just saying in a normal voice, okay, so I’m crying now. It’s like being both emotional but also not at all emotionally invested in it. You just take note of it and how it’s making you feel. Anyway. A decade. That’s a long fucking time.

So. I’m going to go to Peru. To take drugs. Well, not just take drugs, but to do the whole ayahuasca ceremonies. I read about this a couple of years ago and I really wanted to do it but financially it just wasn’t an option. Now that I’ve hit the point that ECT has become a serious discussion, and we have a little money, I’m trying something else first. I’ve been reading a lot about the use of psychedlics in the treatment of severe depression, about ketamines and stuff. I mean, actual scientific studies, though it’s difficult to do studies in the US, obviously. Anyway, a couple of years ago I read a really impressive article in National Geographic, a woman who’d struggled with severe depression all her life and gave up on normal treatments that weren’t getting the job done and decided to try something completely different.

So, that’s where I’m going. To that exact place. I’d talked with the woman back when I originally read the article, and she gave me even more information. I’ve read other studies, and the success rate is pretty high, and people who get relief seem to never slip back into it. Apparently, it outright changes your life. And at this point, given all I know about meds and ECT, and the lack of scientific understanding as to what causes depression and how the meds and ECT work, I can’t see any reason to favor them over trying this. So I am just doing something unbelievably atypical for me and going and doing it. In the end it doesn’t feel any crazier than the past decade I’ve spent trying to treat this medically.

Which means between now and then I have to wean off the current meds. So the next few months might be messy for me but we’ve talked about it and unlike any other time I’ve slipped down we’re expecting it. Whether that makes a difference I don’t know. I think even my therapist is excited about the idea, and ever since I first brought it up she sends me the occasional email about psychedelics and depression. So, um, there you have it.

As an update since first writing this, I’m finally completely off the meds since about a week and a half ago. The side effects have ranged from fascinating to wanting to punch people in the face for no real reason. This is my adventure, as it currently stands. More to come.

(hey there, “future-Paul, circa 2012” here, again. It took almost a year, but I finally started telling the story of my trip to Peru…)